3'3 diindolylmethane

3'3 diindolylmethane

3,3'-Methylenebisindole；Diindolylmethane；DIM

CAS Number:1968-05-4

3,3’-Diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol, a ptochemical produced by the breakdown of the glucosinolate glucobrassicin found in cruciferous vegetables. At 10-30 µM, it demonstrates anticancer and chemopreventative effects involving Nrf2 induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA metlation activities.^1,2,3 Furthermore, at 0.3 µM DIM was shown to act as a potent radioprotector and mitigator of the effects of ionizing radiation exposure by stimulating an ATM-driven DNA damage-like response and NF-κB survival signaling in cultured epithelial cells.